منابع مشابه
PKM2, STAT3 and HIF-1α
The M2 isoform of pyruvate kinase, highly expressed in tumor cells, is known to engage a feed forward loop with the glycolysis master transcription factor HIF-1α. Gao and co-authors recently showed that dimeric PKM2 localizes to the nucleus in highly proliferating cancer cells, where it regulates in vivo growth by acting as a protein kinase and directly activating STAT3. STAT3 is therefore a no...
متن کاملNickel ENMs Activate HIF-1α
Scientists Investigate Burned Gulf Spill Emissions Much of the oil spilled during the BP Deepwater Horizon disaster in the Gulf of Mexico was burned to keep it from reaching the shoreline or harming sea life. NOAA scientists have analyzed the gas and aerosol emissions resulting from the burning of the spilled oil and found that over a 9-week period more than 1 million pounds of black carbon wer...
متن کاملPhospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability
Hypoxia-inducible factor-1α (HIF-1α) is a master transcriptional regulator of cellular response to hypoxia. In normoxia, HIF-1α is degraded through the prolyl hydroxylase (PHD) and von Hippel-Lindau (VHL) ubiquitination pathway. However, it is unknown whether PHD and VHL exert their enzymatic activities on HIF-1α separately or as a multiprotein complex. Here, we show that phospholipase D1 (PLD1...
متن کاملHIF-1α induction during reperfusion avoids maladaptive repair after renal ischemia/reperfusion involving miR127-3p
Ischemia/reperfusion (I/R) leads to Acute Kidney Injury. HIF-1α is a key factor during organ response to I/R. We previously demonstrated that HIF-1α is induced during renal reperfusion, after ischemia. Here we investigate the role of HIF-1α and the HIF-1α dependent mechanisms in renal repair after ischemia. By interference of HIF-1α in a rat model of renal I/R, we observed loss of expression an...
متن کاملHIF-1α in heart: protective mechanisms.
Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that directs many of the cellular responses to hypoxia. In these studies, we have used a mouse model containing a cardiac-specific, oxygen-stabilized, doxycycline (Dox)-off regulated HIF-1α transgene to probe the role of HIF-1α in cardioprotection. Hearts used in these studies were derived from wild-type (WT), noninduced (Non-I), an...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2005
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20050322-01